When a city is filled with so many pizza spots that locals argue over the best slice, you know you’re in good hands. From family-run pizzerias slinging classic New York pies to modern spots with brick-oven flair, Port St. Lucie delivers the perfect fix for every pizza craving.
Let’s get to it.
Casa Vincenzo Pizzeria
Walking into Casa Vincenzo Pizzeria feels like finding the neighborhood spot everyone wishes they had close by. Classic Italian pies take center stage with 14 and 16 inch rounds, so no one leaves hungry. If you prefer square over circle, the thick Brooklyn Sicilian delivers a glorious corner crunch. The Grandma Pie offers fresh mozzarella and basil on a golden-edged slab. Even gluten-free diners have options.
The signature Casa Vincenzo pie includes pepperoni, sausage, peppers, mushrooms, and onions—a true greatest hits collection. For something more refined, the Prosciutto di Parma pie arrives topped with arugula, Parmesan, and a drizzle of balsamic. The small dining room seats about 25, and pickup lines do form around lunch. Everything from sauce to mozzarella is made in house, which is exactly what you hope for. They also offer subs, salads, garlic knots, and a rotating dessert selection. Whole pies range from $16 to $23, and slices are priced for a quick grab. If you want real deal pizza without stress, Casa Vincenzo Pizzeria has it nailed.
Francesca’s Pizza
Inside Francesca’s Pizza in Port St. Lucie, you’ll find classic New York–style pies with thin, floppy crusts perfect for folding. You can smell the scratch-made dough moments before you reach the counter. Signature options include the Blakley pie with house cheese, sausage, and onions, plus a Buffalo Chicken pie for a spicier kick. They even offer a breakfast pizza with an eggy crust that fits right into a brunch menu.
Beyond pizza, the menu features parm poppers, cheesy garlic bread, and an Upstate Cheesesteak. Gluten-free diners are well accommodated with a separate prep zone and dedicated fryer. The beer selection stands out for a casual spot, and there’s a wine list if you prefer. Bar seating and TVs keep the atmosphere laid-back, while high chairs and a kids’ menu cater to families. Prices stay moderate, so feeding a group won’t break the bank. Francesca’s Pizza delivers on that cozy, neighborhood-joint promise with friendly service and consistently solid pies.
Blaze Pizza
At Blaze Pizza, the process is like an assembly line for your perfect pie. You choose a base, then load it with fresh mozzarella, roasted vegetables, chicken sausage, or any combination you want. The pizza goes into an open-flame oven that bakes it in about three minutes, making it a solid choice for a quick lunch or a casual family dinner.
The interior has an industrial-modern design with bright lighting and high-top tables that invite conversation. You can opt for gluten-free crust, keto-friendly dough, or their classic hand-stretched base. Each dough is made from scratch on site rather than brought in frozen. Pricing stays reasonable unless you go wild on add-ons, which is easy to do. There’s plenty of parking, and if you end up waiting, at least there’s a salad option for anyone who doesn’t eat pizza. The vibe is casual, and no one will judge your unusual topping combo. Blaze Pizza delivers a fast, customizable meal that fits both your schedule and your taste.
Mama’s Italian Restaurant & Pizzeria
At Mama’s Italian Restaurant & Pizzeria, over thirty years of Bronx-style dough tossing shows in every slice. The crust strikes a perfect balance—neither cracker-thin nor overly floppy. Gluten-free options are available without any judgment. You can dine in, have pizza delivered, or pick up curbside to enjoy in your car.
Inside, the dining room is cozy and accessible with booths, high chairs, and a kids’ menu. You’ll spot families, after-school crowds, and solo slice seekers. Pizza choices range from a classic Margherita to a creative Taco Pizza. All pies use house-made Bronx dough, fresh mozzarella, and signature sauce. The menu also includes calzones, subs, pasta dishes, and house-made tiramisu. Prices stay in a moderate range so you can try a few items without worrying about the bill. Regulars say the staff treats you like family, which makes each visit feel warm and welcoming. At Mama’s, you get authentic New York–style pizza and genuine hospitality.
LaMattina’s Trattoria & Pizza Bar
Tucked into the Torino Lakes strip plaza, LaMattina’s Trattoria & Pizza Bar feels like the neighborhood spot every suburb wishes it had. You immediately notice the aroma of fresh dough and the friendly shouts of order numbers at the pickup counter. It’s family-owned, with Michael LaMattina working alongside his parents and other relatives. Open since late 2022, it already feels as settled as a decades-old pizzeria thanks to constant pies from a 500-degree brick oven.
Pizza takes center stage with hand-tossed New York crusts in 14- and 16-inch sizes plus a gluten-free option. There’s even a crispy square “18th Ave” pie that merges Detroit and Brooklyn styles. Topping choices are endless, but the signature pies shine brightest. The Antoinette offers a breaded chicken cutlet that lives up to expectations. Anita’s Margherita dresses up the classic with ricotta and buffalo mozzarella.
Grab a seat at the bar or on the patio to catch a game on one of three big TVs or watch artists doodle on chalk tables. Prices stay moderate. Beyond pizza, the menu features garlic knots, house-made pastas and a dessert case full of gelato. Everyone feels at ease here, from picky aunts to hungry kids.
Roma Pizzeria and Restaurant of Sandpiper
In the Morningside Boulevard neighborhood, Roma Pizzeria and Restaurant of Sandpiper feels like a true local fixture. The Catalano family maintains scratch-made dough and fresh salads in a cozy space with booths and a working counter kiosk. Free parking sits just outside.
Pizza options include thin New York-style slices and thick Sicilian squares. The Grandma’s Pizza, topped with chopped plum tomatoes and fresh mozzarella, remains a best-seller. The White Spinach pie combines ricotta and seasoned greens. For a loaded option, the Supreme stacks sausage, pepperoni, onions and peppers. Lunch specials pair a pizza slice with a drink for a quick meal. Beyond pizza, the menu offers hand-rolled calzones, bruschetta, in-house meatballs and pasta dishes. Desserts include classic cannoli and seasonal cakes. Curbside pickup and delivery serve busy customers, while dine-in guests enjoy family-friendly booths. Prices fall in a moderate range, making this spot a reliable choice for both midweek meals and weekend gatherings.
Tavola Pizza
Since 2012, Tavola Pizza at Boulevard Shoppes has offered inventive pies that appeal to adventurous palates. Surfboards on the walls and a laid-back vibe set the scene for pizza with unique toppings. The hand-tossed crust strikes a balance between thin and thick.
Signature options include the Life’s a Peach, topped with prosciutto and fresh peach slices, and the Epic with white-truffle oil, mushrooms and a mozzarella blend. Sauce choices range from classic tomato to buffalo or honey garlic, and customers can build their own pie from seven sauce bases. Tavola also serves garlic knots, zeppole and a rotating list of Florida craft beers. Gluten-free and cauliflower crusts are available on ten-inch pies for an extra charge. The open counter ordering keeps the line moving. Seating fills quickly when local sports air on the TV. Takeout and local delivery meet demand for busy weeknights. Community partnerships and sponsorships make Tavola a neighborhood favorite.
Da Vinci’s Italian Grill
On US-1, Da Vinci’s Italian Grill serves recipes handed down since the 1950s. Brothers Anthony and Dominic continue the family tradition in a casual dining room with low lighting and Italian tunes. The restaurant sits next to free parking and offers seating for large families or small groups.
The pizza menu features hand-tossed New York pies, thick Sicilian squares and Grandma-style rectangles. Toppings range from a triple pepperoni to the All Meat with sausage, ham and pepperoni. Vegetarian diners can choose the Veggie Pie or the Venezia with artichokes and mushrooms. A dedicated oven and separate prep station ensure gluten-free pizzas avoid cross-contamination. Beyond pizza, Da Vinci’s serves classics such as chicken-carbonara, seafood linguine and baked ziti. The Bianca pizza with ricotta and the chicken-bacon-ranch option add variety. Prices remain moderate, and the early closing time around 8:30 PM means dinner guests should arrive before evening rush. A rewards program benefits regulars with discounts and free menu items.
Bella Roma Bakery & Pizzeria
In Port St. Lucie, Bella Roma Bakery & Pizzeria has served the Brancaccio family’s recipes for over forty years. Located on Riomar Drive, the counter displays tray after tray of cookies, fresh cannoli and Italian bread baked each morning. Regular visitors arrive early for pastries, and families return later for dinner. Every dough and sauce batch starts from scratch each day.
Pizza takes center stage with options like Grandma’s, Sicilian thick-crust or hand-tossed New York style. A gluten-free 12-inch crust is also available. The classic Margherita features rich mozzarella and tomato sauce, while the Meat Lover’s pie piles on sausage, pepperoni and house-made meatballs. Prices remain reasonable, with a cheese pizza starting at around $12 and bakery treats priced between coffee and a movie ticket. Seating is limited to about fifteen to twenty spots. Most customers choose takeout or delivery instead, and the bakery offers catering trays ideal for larger gatherings. Weekday lunch visitors can grab a hot sub or lobster tail pastry from the case before heading back to work.
Carrabba’s Italian Grill
At Carrabba’s Italian Grill in Port St. Lucie, the open kitchen centers on a wood-burning grill and displays of fresh ingredients. The aroma of scratch-made sauces wafts through the dining room. Pizzas emerge from a wood-fired Italian oven, each crust showing a light char and crisp Neapolitan texture. The Margherita pizza pairs tomato, basil and fresh mozzarella in a classic presentation. For a more robust bite, the Italian Chicken pizza adds scallions, pine nuts and two cheeses.
Carrabba’s maintains its family-kitchen roots despite being a chain. Dough and sauces are made from scratch each day, following original family recipes. Patrons will find chicken scallopini, seafood linguine and hearty pasta dishes alongside the pizza menu. Prices range from $10 to $17 for pies. On Friday evenings, the dining room hums with conversation as families and friends gather. For those on the go, Carrabba’s provides efficient takeout service and full catering options, from party trays to boxed meals.
Tutto Fresco Restaurant
Since 2012, Tutto Fresco Restaurant has blended Sicilian family traditions with a passion for pizza. Located at the entrance to PGA Village, the 8,000-square-foot venue offers a main dining room, a cozy lounge, and a climate-controlled wine room. Outside, a spacious patio bar comes alive with live music when weather permits.
Brick-oven pizzas earn praise for their hand-stretched dough and generous toppings. The White Truffle pizza features truffle oil that delivers real flavor, while the Meat Lover pie combines every meat option in one indulgent creation. Classic Margherita fans enjoy fresh tomatoes, basil, and mozzarella on a crisp crust. Most dishes stay under thirty dollars, making quality dining accessible.
Complimentary valet service adds convenience. The curated wine list waits in its own cool room, ready to pair with any meal. Whether you’re entertaining family, planning a rehearsal dinner, or grabbing takeout, Tutto Fresco covers all the bases. Their pizzas hold up to the hype, making each visit worthwhile.
Pastaio Handmade Pasta•Pizza
In Tradition Village Square, Pastaio Handmade Pasta•Pizza strikes a balance between authentic family-run charm and creative flair. An open kitchen lets you spot chefs hand-rolling pasta before it’s doused in truffle oil or piled high with local vegetables.
Their brick-oven pizzas capture Neapolitan spirit with thin, chewy crusts and crisp, crackling edges. You’ll find traditional toppings alongside bold choices like kung fu chicken or salmon piccata. Goat cheese appears on several pies, while the handmade sausage and spinach-artichoke pesto combo earn loud praise. Prices stay reasonable for fresh pasta and stone-fired pie, so you can sample starters such as burrata or meatballs without a second thought.
Inside, the dining room suits families, date nights and groups that linger over drinks. Seasonal salads and house-made cannoli accompany crafted cocktails. Since the Lamarra family opened in late 2024, Pastaio has become a Friday favorite, yet you can still find an open table on a Tuesday evening.
