A great sandwich is more than just bread and fillings…it’s a local obsession. Port St. Lucie is packed with delis, cafes and shops that stack their sandwiches tall and make every lunch feel like a treat.
Let’s get to it.
Two Fat Guys Italian Gourmet Deli
At Two Fat Guys Italian Gourmet Deli in Port St. Lucie, you can expect a hero sandwich done right by a Brooklyn transplant who really knows his bread. Tucked into a strip mall on SW Gatlin Boulevard, this spot keeps things simple and focused on flavor rather than décor.
The menu highlights king-sized sandwiches like the Buffalo Chicken Cutlet Roll and Chicken Parm, piled high on sturdy Italian bakery hero rolls or soft sub loaves. Everything is cut thick, from the premium Boar’s Head meats to their own house-pulled mozzarella. Don’t miss the homemade sausage and rice balls, straight from the kitchen.
Lunch is prime here, with more hot and cold Italian heroes than you can shake a stick at. Classics include the Manhattan Special and Anthony Special Sub, plus eggplant parm heroes or vegan swaps for meatless eaters. Portions are New York-large and prices hover in that $8 to $15 sweet spot. Most customers opt for carryout, but there are a few deli tables if you’d rather linger over your sandwich.
Meeter’s Deli
Meeter’s Deli in Port St. Lucie keeps things straightforward and satisfying with counter service in a cozy corner spot. The bread is baked in-house daily, from sturdy rye loaves for a classic Reuben to fluffy sub rolls for oversized, ingredient-packed hoagies.
Cold cuts are sliced to order, featuring the Thumann’s brand for anyone who knows their deli meats. There’s no MSG here, and gluten-free meats or bread are available on request. Classics like the Reuben, Rachel, Club and Tuna Melt share space with a hot cheesesteak and a Cuban Sandwich. You’ll also find a Buffalo Chicken Salad and scratch-made sides like coleslaw and potato salad.
Most sandwiches land just under eight dollars alone, and combos with a drink and side still stay below typical sit-down lunch prices. The family-run team is welcoming and efficient. Seating is limited, so most folks take their generous sandwiches to go. Meeter’s stays open for lunch and early dinner most days, closing on Sunday.
NY Sandwich Co
In St. Lucie West, NY Sandwich Co serves both morning and lunchtime cravings from a modest strip mall location. Their menu fits on one page but covers everything from bacon-egg-and-cheese bagels to hot pastrami on rye. Breakfast options run until mid-afternoon and include protein-packed bagel or kaiser sandwiches with steak, pastrami or Taylor’s Ham.
Lunch brings piled-high cold subs featuring turkey, roast beef or pressed Cubans on garlic bread. Signature sandwiches like the New Yorker, Little Italy and Queens layer cured meats with melty cheeses, roasted peppers, ricotta or pesto where it works. Bread choices include fresh Italian rolls, kaiser rolls and wraps.
Sandwiches generally range from $8 to $17. You can add chips or fries for a small upcharge. Dine-in seating is limited, making this a popular grab-and-go spot. Catering options include 3-foot heroes and big trays for parties. Vegetarian fans can choose a Caprese or portabella sub, but there’s no gluten-free menu. Open daily for breakfast, lunch and catering, they close on Sunday.
Shakra’s Deli
Since 1972, Shakra’s Deli has been a family-run mainstay on the Treasure Coast, operating from two no-frills locations. They focus on what works: counter service, time-tested recipes and hot and cold sandwiches that generations have returned for.
The Roast Beef Supreme stars thin-sliced homemade top round in Burgundy wine gravy, topped with provolone on a toasted sub roll that holds up to each bite. The hand-rolled Meatball Supreme and scratch-made cheese steak also draw regulars, thanks to fresh-off-the-slicer steak and bread that’s never stale.
Every order lets you choose sub, wrap or salad. Vegetarian options include the Cosmo sub, while Greek and Caesar salads make a lighter meal. Sides range from steak fries to homemade potato salad. Gluten-free wraps and keto subs are available for special diets. Sandwiches average $9 to $12, and portions are generous enough that some customers split them. The staff stays hands-on, ensuring most guests leave happy—often with catering trays in hand for bigger events.
Which Wich Superior Sandwiches
When you step into Which Wich Superior Sandwiches in Port St. Lucie, you’re met with their signature bag-and-marker ordering system. It feels playful, like jotting down your lunch order in class, but the sandwich options are all grown-up.
Counter service welcomes families and weekday lunch crowds, and you’ll find indoor-outdoor seating in a compact strip-mall space along Federal Highway. Signature sandwiches such as The Wicked—five meats and three cheeses—and the Ultimate BLT offer big flavor and hearty portions. Traditionalists will appreciate the turkey pastrami, while veggie lovers can stack a Veggie Wich with vegan-friendly toppings.
Bread choices cover classic white and wheat, a gluten-free “Cloud’WICH” and even lettuce wraps for a keto-friendly option. Regular wiches are just under seven dollars, and super-sized versions top out around $13. All ingredients are sliced fresh each day. With online ordering, catering services and walk-up convenience, this spot is made for people who like their lunch exactly how they want it.
Berry Fresh Cafe
Discovering a cafe that takes breakfast and lunch seriously can be a treat, and Berry Fresh Cafe delivers beyond its strip-mall roots. The menu boasts Florida-style favorites like hearty grilled Reubens, signature smash burgers, and a crab cake sandwich made with real lump crab that has a hint of sweetness. Vegans aren’t left out, either—those hippie picnic sandwiches are so good you won’t miss the meat.
You’ll find plenty of bread choices, too, from marble rye to buttery croissants and even gluten-free loaves. Proteins feel homemade, with house-roasted turkey, scratch-made tuna salad, and hand-breaded fish. For sides, you won’t be stuck with just fries—opt for red bliss potato salad or a light quinoa salad. Portions are just right, and the half-sandwich pick-two combo helps you keep things lighter if you prefer.
Breakfast runs until mid-afternoon every day, perfect for late risers. The casual tables, dog-friendly patio, and warm, friendly staff give the place a small-town vibe, even along the busy Florida coast.
Port Saint Wich
Step into Port Saint Wich, and the scent of pressed Cuban bread and roasting pork announces you’re in for something special. Tucked in a SW Port St. Lucie strip plaza, this family-run spot has been humming along for over 18 years.
Their classic Cubano shines with daily-baked bread, roast pork and ham sliced and sizzled to order. The Pan con lechón is piled high with savory onions, and the steak and fish sandwiches are always fresh off the grill. The Mayrita sandwich steals the show with two crispy croquetas tucked inside.
Don’t skip the pastries—guava-and-cheese is a staple, and their flan disappears fast. Prices land in the mid-range, and sandwich portions often feed two unless you’re really hungry. Breakfast here centers on strong Cuban coffee and a sweet treat, while lunchtime brings a steady stream of guests after hot, grilled sandwiches.
Seating is limited but relaxed, wheelchair accessible, and there’s free Wi-Fi for those who want to linger over a shake or an ice-cold Materva.
Charleys Cheesesteaks and Wings
Charleys Cheesesteaks & Wings on SW Gatlin Boulevard serves big flavors in a fast-casual setting. You order at the counter, and soon enough a hot, hearty sandwich appears on a perfectly toasted roll. Choose the signature Philly cheesesteak or something saucier like Kentucky Bourbon. Chicken lovers can grab Teriyaki or Buffalo versions.
All steak is USDA choice, and chicken is all-white meat. Onions, peppers and mushrooms get chopped fresh on the grill, then melted provolone or sharp cheddar tops it off. Vegetarians can enjoy the Veggie Delight, loaded with sautéed mushrooms and veggies, and the staff will adjust it for stricter diets on request.
Wings come in generous or extra-large orders, and party trays of three-inch cheesesteaks make catering a breeze. Whether you dine in at a few limited tables, pick up a boxed meal, or get delivery, everything’s made to order.
They stay open past 9 PM, so a late dinner doesn’t feel rushed. It’s practical, unpretentious, and just a little indulgent.
Jersey Mike’s Subs
At Jersey Mike’s Subs, the focus is on classic deli flavors with a modern twist. You’ll notice fresh white and wheat rolls baked daily, and some locations even offer gluten-free bread. Cold subs like the #13 Original Italian and the Jersey Shore’s Favorite are deli-style perfection.
Hot sandwiches aren’t far behind. The steak and chicken cheesesteaks sizzle on the grill, and you can request any sub toasted or warm. Premium meats from Hormel and Boar’s Head show up in generous layers, and seasonal local produce keeps the tomatoes and greens crisp. Vegetarians can opt for the garden veggie sub with provolone, and vegans can build a meal by choosing carefully.
Even a 6-inch sub comes in at a full lunch size. The dine-in area seats around 20 to 30 people in a bright, relaxed strip-mall space. Most guests carry out, but you’ll also find catering options, app ordering, and occasional drive-thru service.
Panera Bread
Panera Bread in Port St. Lucie balances a casual work-friendly vibe with a solid menu. Modern seating, outdoor tables, and the buzz of laptop-tappers set the tone. The real star is the bread: sourdough, tomato basil, and asiago cheese loaves all bake fresh daily.
Sandwiches like the Chipotle Chicken Avocado Melt and the Mediterranean Veggie come on those freshly baked loaves, hot or cold, and portions feel generous. Croissant Toast sandwiches, such as the Croque Monsieur, add a French twist. Gluten-free bread and half-size options make it easy to customize your meal.
Breakfast runs until 10:30 AM, then the menu shifts to salads, soups, and a wide array of sandwiches, with calorie counts and allergy info posted clearly. House-roasted turkey, deli-brand meats, and rotating vegetarian and vegan bowls keep things fresh. Dairy-free spreads and seasonal soups round out the choices.
Prices hover in the mid-range: more special than typical fast food, but still accessible. It’s a comfortable spot for everything from solo work sessions to casual catch-ups.
Jimmy John’s
When you need a quick sandwich fix, Jimmy John’s delivers. The menu goes from classics like the #5 Vito with Italian meats or the turkey-packed #1 Pepe to the gargantuan Gargantuan, piled high with almost every meat on offer.
Most shops use freshly baked French bread, either plain or with sesame seeds, while the Unwich lettuce wrap is perfect for a low-carb choice. Vegetarians can try the #6 Veggie with lettuce, tomato, cucumber, avocado spread and optional vegan mayo.
Regular subs run about $6 to $8 and come generously filled. Though these are mostly cold sandwiches, you can always ask to have yours toasted. Chips and cookies add just a few dollars more if you want a side.
Locations feature bright lighting, simple counter service and a handful of seats, though most people grab takeout or delivery. Jimmy John’s stays open through lunch and into early dinner on weekdays and wraps up a bit earlier on weekends. Online ordering is user-friendly, and large sandwich platters can easily feed a group.
