The best bars & nightlife in Murphysboro

8 bars & nightlife we’ve checked and stand behind — with the story on each one. Not a ranking; a record.

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Nightlife · 8 places · showing the latest additions first

Craving a grown-up dinner that still feels like a treat after a long week, hit up Flame Bar And Grill for a classic steakhouse menu, fine…

501 E Walnut St (Carbondale)

“Craving a grown-up dinner that still feels like a treat after a long week, hit up Flame Bar And Grill for a classic steakhouse menu, fine wines, and handcrafted cocktails in a warm, refined room with impeccable tableside service that makes even a random Tuesday feel a little fancy.”

From the Southern Illinois newsletter, September 11, 2026

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Underground Public House keeps things local, seasonal, innovative with craft butchered meats, Southern Illinois produce, and cocktails that…

717 S University Ave (Carbondale)

“Underground Public House keeps things local, seasonal, innovative with craft butchered meats, Southern Illinois produce, and cocktails that actually earn the word innovative. Pair it with their rotating tap list of craft beers from around the region and world, then call it your weekly treat you definitely deserve.”

From the Southern Illinois newsletter, September 17, 2026

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Big Muddy Brewing keeps it local with beer, bourbon, and root beer, plus events and an event space for when the whole crew shows up. Make…

1430 N 7th St

“Big Muddy Brewing keeps it local with beer, bourbon, and root beer, plus events and an event space for when the whole crew shows up. Make it a mini escape this week... they’ve even got camping.”

From the Southern Illinois newsletter, September 12, 2026

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Midland Inn

Nightlife

When dinner indecision hits, Midland Inn has you covered with Mexican favorites, hand-pattied burgers, fried shrimp and catfish, and a…

7570 Old Hwy 13 · ✓ checked Aug 17

“When dinner indecision hits, Midland Inn has you covered with Mexican favorites, hand-pattied burgers, fried shrimp and catfish, and a little smokehouse BBQ, all with laid-back bar vibes and margaritas locals rave about. Keep it simple this week and let them cook.”

From the Southern Illinois newsletter, August 29, 2026

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Buckwater Brew Works & Whiskey House pours the good stuff alongside hand-crafted pub fare, with wings worth planning around. Go for a pint…

213 E Main St (Carbondale)

“Buckwater Brew Works & Whiskey House pours the good stuff alongside hand-crafted pub fare, with wings worth planning around. Go for a pint and stay for the weekly bingo, trivia, and karaoke... basically the midweek morale boost Southern Illinois deserves.”

From the Southern Illinois newsletter, September 13, 2026

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Kite Hill Vineyards pours award-winning Southern Illinois wines grown in the Shawnee Hills AVA, with a lineup that actually showcases local…

100 Tasting Room Rd (Carbondale)

“Kite Hill Vineyards pours award-winning Southern Illinois wines grown in the Shawnee Hills AVA, with a lineup that actually showcases local stars like Chambourcin, Chardonel, and Viognier. This week, grab a bottle, linger for the view, and feel smug you didn’t drive to Napa.”

From the Southern Illinois newsletter, September 14, 2026

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If you need a place to shake off the week, Levels Nightclub brings live entertainment, plenty of dancing, karaoke you’ll brag about later,…

760 E Grand Ave (Carbondale) · ✓ checked Aug 26

“If you need a place to shake off the week, Levels Nightclub brings live entertainment, plenty of dancing, karaoke you’ll brag about later, and a solid beer lineup to keep things easygoing, making it an easy yes for a spontaneous Southern Illinois night out.”

From the Southern Illinois newsletter, August 31, 2026

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Whether you’re into clean, traditional styles or curious one-off batches, Molly's Pint Brewpub pours small-batch Irish pub vibes brewed…

12 N 13th St

“Whether you’re into clean, traditional styles or curious one-off batches, Molly's Pint Brewpub pours small-batch Irish pub vibes brewed right in Murphysboro. 007 and a spicy Jalapeño India Session Ale, plus low-key music and paint-by-the-pint nights.”

From the Southern Illinois newsletter, September 17, 2026

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