The best restaurants in Murphysboro

23 restaurants we’ve checked and stand behind — with the story on each one. Not a ranking; a record.

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Restaurants · 23 places · showing the latest additions first

Domino's Pizza

Restaurants

Delivery, carryout & dine-in chain offering a wide range of pizzas, plus a variety of other dishes & sides.

125 Muddy Monster Rd

“Delivery, carryout & dine-in chain offering a wide range of pizzas, plus a variety of other dishes & sides.”

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Hardee's

Restaurants

Fast-food chain serving fried chicken, big burgers & made-from-scratch breakfast biscuits.

340 Walnut St

“Fast-food chain serving fried chicken, big burgers & made-from-scratch breakfast biscuits.”

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Subway

Restaurants

Casual counter-serve chain for build-your-own sandwiches & salads, with health-conscious options.

1617 Walnut St Unit A

“Casual counter-serve chain for build-your-own sandwiches & salads, with health-conscious options.”

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From Pollo Loco to Papa’s Special rice bowls and sizzling fajitas, Sergio’s Mexican Restaurant leans chicken in the best way, with plenty…

1160 E Main St (Carbondale)

“From Pollo Loco to Papa’s Special rice bowls and sizzling fajitas, Sergio’s Mexican Restaurant leans chicken in the best way, with plenty of beef and seafood backup. Pair it with a lime margarita or a mangonada and call it a solid Southern Illinois weeknight win.”

From the Southern Illinois newsletter, September 3, 2026

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Gresa's Cafe

Restaurants

If you’re craving a no-frills, family-run spot that turns out hearty breakfasts and classic homestyle plates, Gresa's Cafe delivers. Warm…

108 N Chestnut St (De Soto)

“If you’re craving a no-frills, family-run spot that turns out hearty breakfasts and classic homestyle plates, Gresa's Cafe delivers. Warm vibes, generous portions, and a menu with real variety make it an easy meet-up choice this week when you want simple food done right.”

From the Southern Illinois newsletter, September 7, 2026

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Craving real-deal barbecue that actually tastes like wood smoke and patience? Bandana's Bar-B-Q Carbondale Il is known for award-winning,…

309 E Main St (Carbondale)

“Craving real-deal barbecue that actually tastes like wood smoke and patience? Bandana's Bar-B-Q Carbondale Il is known for award-winning, hickory-smoked ribs, Family Feasts and Combo Platters with scratch-made sides, plus a lineup of house sauces so you can go sweet, spicy, or bravely mustardy tonight.”

From the Southern Illinois newsletter, August 26, 2026

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Papa Johns Pizza

Restaurants

Pizza take-out & delivery chain offering classic & specialty pizzas, plus wings, sides & desserts.

602 E Grand Ave (Carbondale)

“Pizza take-out & delivery chain offering classic & specialty pizzas, plus wings, sides & desserts.”

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Sam's Cafe

Restaurants

When the gyro craving hits and only a pile of tender, saucy goodness will do, Sam's Cafe comes through with mouthwatering gyros, hearty…

521 S Illinois Ave (Carbondale)

“When the gyro craving hits and only a pile of tender, saucy goodness will do, Sam's Cafe comes through with mouthwatering gyros, hearty burgers, pizza puffs, and genuinely good coffee. Easy, local, and reliably satisfying, it’s the kind of no-fuss spot you’ll add to the weekly rotation.”

From the Southern Illinois newsletter, August 28, 2026

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Italian Village

Restaurants

Italian Village is that longtime Carbondale staple your parents introduced you to and it still hits just right. Think classic red-sauce…

405 S Washington St (Carbondale)

“Italian Village is that longtime Carbondale staple your parents introduced you to and it still hits just right. Think classic red-sauce comfort, pizza-night energy, and the kind of wood-paneled nostalgia that makes catching up with friends feel effortless.”

From the Southern Illinois newsletter, September 11, 2026

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Pat's BBQ

Restaurants

Whether you're after tender brisket, meaty ribs, or classic pulled pork, Pat's BBQ keeps it simple in a

111 Tower Rock Ln · ✓ checked Aug 26

“Whether you're after tender brisket, meaty ribs, or classic pulled pork, Pat's BBQ keeps it simple in a relaxed space that feels just right after a long day. Solid, satisfying, and proudly local... the kind of spot Southern Illinois folks keep in their back pocket for dependable barbecue.”

From the Southern Illinois newsletter, August 31, 2026

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Aban Kitchen

Restaurants

Whether you’re in a shawarma mood or corralling the crew for family-style platters, Aban Kitchen nails those cozy Middle Eastern flavors…

114 S Illinois Ave (Carbondale)

“Whether you’re in a shawarma mood or corralling the crew for family-style platters, Aban Kitchen nails those cozy Middle Eastern flavors with plenty of vegetarian options that actually slap. Skip the same-old this week and let the spices do the heavy lifting for weekday sanity.”

From the Southern Illinois newsletter, August 29, 2026

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Tequila's

Restaurants

When you want sizzling plates and a salt-rimmed margarita without leaving town, Tequila's hits the spot. Think sprawling menu from burritos…

100 N Glenview Dr #2275 (Carbondale)

“When you want sizzling plates and a salt-rimmed margarita without leaving town, Tequila's hits the spot. Think sprawling menu from burritos and nachos to seafood, steak, and vegetarian specialties, plus that easygoing, locals-and-students vibe that makes weeknights feel like minor celebrations.”

From the Southern Illinois newsletter, August 23, 2026

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Whether you need a dessert spread for a backyard birthday, a work thing, or just an excuse to spoil the fam, Bake Me Happy Food Co turns…

2031 S Illinois Ave Unit B (Carbondale)

“Whether you need a dessert spread for a backyard birthday, a work thing, or just an excuse to spoil the fam, Bake Me Happy Food Co turns local love into custom sweets that actually taste homemade. Hit them up this week and let someone else handle the sugar magic.”

From the Southern Illinois newsletter, September 10, 2026

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Need a midweek morale boost? 17th Street Barbecue is the home of Apple City Baby Back Ribs, pulled pork, and those baked beans locals won’t…

32 N 17th St

“Need a midweek morale boost? 17th Street Barbecue is the home of Apple City Baby Back Ribs, pulled pork, and those baked beans locals won’t stop talking about, all dusted with their cult-favorite Magic Dust seasoning, and named Best Barbecue in Illinois by Food Network.”

From the Southern Illinois newsletter, August 29, 2026

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Craving maki, a sizzling hibachi fix, or a no-fuss bento that actually fills you up? Yamato Steak House Of Japan has everything from chef’s…

1013 E Main St (Carbondale)

“Craving maki, a sizzling hibachi fix, or a no-fuss bento that actually fills you up? Yamato Steak House Of Japan has everything from chef’s special rolls and sushi bar entrées to ramen, teriyaki, and hibachi combos. Put it on your weeknight rotation, your future self will applaud.”

From the Southern Illinois newsletter, August 25, 2026

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Cummare’s

Restaurants

When pasta cravings hit and you want something cozy, Cummare’s in Murphysboro serves homestyle Italian comfort that tastes like Nonna…

1023 Chestnut St

“When pasta cravings hit and you want something cozy, Cummare’s in Murphysboro serves homestyle Italian comfort that tastes like Nonna cooked it. Simple, satisfying plates, friendly vibes, and that just-right Sunday-dinner energy... perfect for a midweek pick-me-up.”

From the Southern Illinois newsletter, September 19, 2026

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Fast-food eatery specializing in Cajun-style fried chicken, plus wings, seafood, breakfast & more.

534 E Main St (Carbondale)

“Fast-food eatery specializing in Cajun-style fried chicken, plus wings, seafood, breakfast & more.”

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Sunny Street Cafe in Carbondale serves feel-good food for breakfast and lunch, started by a dad and now run by his daughter and two sons.…

900 E Walnut St (Carbondale)

“Sunny Street Cafe in Carbondale serves feel-good food for breakfast and lunch, started by a dad and now run by his daughter and two sons. Cozy, straightforward, and just-right tasty, with a specials menu that gives you something new to crave when this week needs an easy win.”

From the Southern Illinois newsletter, August 21, 2026

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Thai Taste

Restaurants

Thai Taste is that reliable weeknight hero for Southern Illinois, serving authentic family recipes made to order with a spice scale from 1…

100 S Illinois Ave (Carbondale)

“Thai Taste is that reliable weeknight hero for Southern Illinois, serving authentic family recipes made to order with a spice scale from 1 to 10. Go big with a 10 or keep it chill at 1, with vegetarian, vegan-friendly picks and thoughtful allergy accommodations.”

From the Southern Illinois newsletter, September 13, 2026

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Changos keeps it simple and satisfying with hefty, flavor-packed burritos that actually fill you up, plus crunchy chips that disappear way…

519 S Illinois Ave (Carbondale)

“Changos keeps it simple and satisfying with hefty, flavor-packed burritos that actually fill you up, plus crunchy chips that disappear way too fast. Order online for an easy midweek win, or loop them in for catering when the whole crew inevitably invites themselves over. Check it out.”

From the Southern Illinois newsletter, September 12, 2026

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Quatro's Deep Pan Pizza has been feeding Carbondale since the '70s, turning an old doughnut bakery into a hometown staple with deep pan…

218 W Freeman St (Carbondale)

“Quatro's Deep Pan Pizza has been feeding Carbondale since the '70s, turning an old doughnut bakery into a hometown staple with deep pan pies and classic pizza-joint energy. Perfect midweek plan: round up the crew, order a big pie, and taste why SIU semesters helped make it a legend.”

From the Southern Illinois newsletter, August 28, 2026

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Munch Station

Restaurants

Munch Station is Carbondale’s go-to for juicy chicken shawarma, classic gyros, and halal-friendly bowls that actually hit the spot. Feeling…

600 E Grand Ave #5 (Carbondale)

“Munch Station is Carbondale’s go-to for juicy chicken shawarma, classic gyros, and halal-friendly bowls that actually hit the spot. Feeling extra, grab the Munch Fries loaded with two meats, toppings, and sauces, or keep it crispy with whole wings... even catfish if you know, you know.”

From the Southern Illinois newsletter, August 27, 2026

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When you're juggling kids' practice, chores, or just don't want to cook, Don Luna keeps it simple with Mexican fast food that lives up to…

2141 S Illinois Ave (Carbondale)

“When you're juggling kids' practice, chores, or just don't want to cook, Don Luna keeps it simple with Mexican fast food that lives up to its motto, fresh, fast and good. A reliable Carbondale go-to for satisfying cravings without slowing down your evening.”

From the Southern Illinois newsletter, August 24, 2026

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