The best restaurants in De Soto

Fast-food chain serving fried fish & shrimp combo meals along with gumbo & funnel cakes.

1156 W Gannon Dr (Festus)

Convenience store-based pizza chain doling out create-your-own pies along with wings.

5997 State Rd B (Hillsboro)

Counter-serve bakery/cafe chain serving sandwiches, salads & more, known for its bread & free WiFi.

1075 W Gannon Dr (Festus)

Lively chain steakhouse serving American fare with a Southwestern spin amid Texas-themed decor.

1351 Shapiro Dr (Festus)

Convenience store-based pizza chain doling out create-your-own pies along with wings.

3625 Athena School Rd

Health-conscious chain featuring blended drinks in varied flavors with fruits & veggies.

955 Veterans Blvd (Festus)

Chain known for steakburgers & milkshakes offering a dinerlike space with retro flair.

999 Veterans Blvd (Festus)

Counter-serve chain specializing in sub & club sandwiches, plus signature potato chips.

1300 Veterans Blvd (Festus)

Delivery, carryout & dine-in chain offering a wide range of pizzas, plus a variety of other dishes & sides.

801 Collins Dr (Festus)

Pizza take-out & delivery chain offering classic & specialty pizzas, plus wings, sides & desserts.

370 Festus Centre Dr (Festus)

No-frills chain specializing in St. Louis-style pies with thin crusts & Provel cheese.

1176 E Gannon Dr (Festus)

Casual counter-serve chain for build-your-own sandwiches & salads, with health-conscious options.

1172 W Gannon Dr (Festus)

Well-known fast-food chain serving grilled burgers, fries & shakes.

802 Lee Ave (Festus)

Simple chain spot offering American diner fare & all-day breakfast, including signature waffles.

1304 Veterans Blvd (Festus)

A menu of customizable Mexican food served in a modern restaurant, plus takeout & catering.

1300 Veterans Blvd A (Festus)

Fast-food burger & fries joint with an old-school feel, including retro drive-in service.

302 Festus Centre Dr (Festus)

Branch of a local chain of family-oriented Italian restaurants serving up pastas, pizzas & entrees.

1606 Galemore St (Festus)

Fast-food chain serving signature beef, chicken & fish sliders, plus extras such as onion rings.

1000 Veterans Blvd (Festus)

Delivery, carryout & dine-in chain offering a wide range of pizzas, plus a variety of other dishes & sides.

10736 Business Rt 21 (Hillsboro)

Casual counter-serve chain for build-your-own sandwiches & salads, with health-conscious options.

10671 MO-21 (Hillsboro)

Popular delivery, carry-out & dine-in chain known for pizza, wings & pasta, plus sides & desserts.

2090 Rock Rd

No-frills chain specializing in St. Louis-style pies with thin crusts & Provel cheese.

1 Jefferson Square

Fast-food chain serving Mexican-inspired fare such as tacos, quesadillas & nachos.

10255 Business Hwy 21 (Hillsboro)

Casual counter-serve chain for build-your-own sandwiches & salads, with health-conscious options.

2108 Rock Rd

Delivery, carryout & dine-in chain offering a wide range of pizzas, plus a variety of other dishes & sides.

2128 Rock Rd

No-frills chain specializing in St. Louis-style pies with thin crusts & Provel cheese.

10906 MO-21 (Hillsboro)

Fast-food burger & fries joint with an old-school feel, including retro drive-in service.

12872 MO-21

Fast-food chain serving fried chicken, big burgers & made-from-scratch breakfast biscuits.

12974 MO-21

Fast-food chain serving Mexican-inspired fare such as tacos, quesadillas & nachos.

12866 MO-21

Family-run eatery offering Italian dishes in a casual yet elegant setting with a bar & wine cellar.

2241 S Brentwood Blvd (St. Louis)

Snug, laid-back eatery offering homestyle American meals, plus a full bar & specialty cocktails.

7201 Piccadilly Ave (St. Louis)

Sophisticated eatery serving up prime rib, shrimp cocktail & other steakhouse classics.

10205 Gravois Rd (St. Louis)

Upscale chain for aged prime beef, seafood & other traditional steakhouse fare in a clubby space.

999 N 2nd St (St. Louis)

Counter-serve chain preparing bowls with pick-your-own bases & toppings, plus salads & wraps.

10758 Sunset Hills Plaza (St. Louis)

Family-owned since 1976, Roper's Ribs turns out hand-rubbed meats slow-smoked 12 hours over hickory for that deeply St Louis-style bark and…

6929 W Florissant Ave (St. Louis)

Creative Tex-Mex grub & specialty margaritas are served in a cheery setting with happy hour.

1235 Washington Ave (St. Louis)

Family-friendly chain eatery offering steaks & Gulf Coast seafood in laid-back surroundings.

1820 Market St (St. Louis)

Tucked inside Union Station Hotel, Station Grille keeps the Fred Harvey spirit alive with traditional American comfort food and the kind of…

1820 Market St (St. Louis)

Outpost of upmarket steakhouse chain known for sizzling, butter-topped beef in an elegant setting

Hyatt Hotel, 315 Chestnut St (St. Louis)

Longstanding, family-owned Italian eatery serving steaks, signature pasta & seafood.

20 S 4th St (St. Louis)

Colorful joint with outdoor seats serving fajitas, tacos & other Mexican classics, plus margaritas.

9570 Watson Rd (St. Louis)

Casual counter-serve chain for build-your-own sandwiches & salads, with health-conscious options.

11005 Riverview Dr (St. Louis)

Casual, modern spot offers an eclectic array of Japanese fare including sushi, plus burgers.

1013 Washington Ave (St. Louis)

Fast-food chain serving chicken sandwiches & nuggets along with salads & sides.

10706 Sunset Hills Plaza (St. Louis)

Branch of a regional chain dispensing hot & cold sandwiches in a simple, counter-serve setting.

614 Washington Ave (St. Louis)

Classic Italian & American fare served in a historic space with a relaxed vibe & weekend live music.

2700 Olive St (St. Louis)

Wood-heavy BBQ spot with big windows offering a modern, meat-centric American menu & whiskey drinks.

900 Spruce St (St. Louis)

Full-service chain bar & grill providing hearty American eats in an informal setting.

9031 Watson Rd (St. Louis)

An Italian menu of pizza, pasta & entrees from a longtime family-owned eatery.

9525 Manchester Rd (St. Louis)

Enduring outpost serving Tex-Mex standards in a casual counter-serve setting or the drive-thru.

9643 Manchester Rd (St. Louis)

Everything from pancakes to breakfast pizza appears on the menu of this lively restaurant.

100 N Tucker Blvd (St. Louis)

Owned by Louie with India steering the front and Chef Joe in the kitchen, Vangel's Restaurant & Bar is that reliable neighborhood spot just…

10017 Manchester Rd (St. Louis)

Local Italian chain serving pizza, pasta & classic entrees in a traditional setting.

8556 Watson Rd (St. Louis)

Quaint eatery offering comfort eats, including breakfast, on scenic property, plus a loft gift shop.

1015 S Sappington Rd (St. Louis)

Counter-service deli chain crafting hearty signature subs, salads & kids' meals in a casual setting.

9532 Manchester Rd (St. Louis)

No-frills chain specializing in St. Louis-style pies with thin crusts & Provel cheese.

1701 Delmar Blvd (St. Louis)

A menu focused on American & Mexican comfort food in a modern, industrial space with exposed beams.

626 N 6th St (St. Louis)

Contemporary alehouse offering draft brews & personal table taps, classic American eats & a patio.

11769 Manchester Rd #4616 (St. Louis)

Open since 1925, this enduring upscale eatery offers steakhouse classics, including steak Diane.

1200 N 1st St (St. Louis)

Unassuming eatery offers Thai & Japanese cooking, including sushi, curries & lunch specials.

403 Watson Plaza (St. Louis)

Roomy haunt with a convivial vibe boasts an eclectic menu of pub grub, happy hour & karaoke night.

3650 S Lindbergh Blvd (St. Louis)

Casual locale offering beefy mains, seafood specialties & drinks in a cool setting with a patio.

10701 Watson Rd (St. Louis)

Bright brunch restaurant specializing in crêpes, elevated European comfort fare & cocktails.

1025 Washington Ave (St. Louis)

Fast-food chain specializing in frozen custard & signature burgers made with Midwest beef & dairy.

10200 Big Bend Rd (St. Louis)

Modern, sculpture-filled Thai restaurant serving carefully plated noodles, curries & more.

1000 Washington Ave (St. Louis)

Counter-serve outpost for American BBQ like ribs, brisket & turkey legs in a bare-bones space.

6300 W Florissant Ave (St. Louis)

Snug locale fixing up sandwiches, açaí bowls & homemade ice cream, plus coffee, shakes & bubble tea.

442 N 4th St (St. Louis)

Long-running multi-cuisine restaurant serving steaks, seafood, & cocktails in an easygoing setting.

9855 Manchester Rd (St. Louis)

High-end steakhouse chain with aged prime beef & classics such as lobster tails.

1855 S Lindbergh Blvd (St. Louis)

Low-key, counter-serve cafe offering sandwiches, baked goods & coffee drinks, plus catering.

211 N Broadway #150 (St. Louis)

A menu featuring an array of classic Mexican dishes in a cantina-style setting with bright decor.

35 N Gore Ave (St. Louis)

Cafe chain for health-minded breakfast, brunch & lunch options such as omelets, salads & soups.

39 N Euclid Ave (St. Louis)

Casual venue serving nutrient-dense bowls and smoothies with vegan options, plus a kids' menu.

227 N Euclid Ave (St. Louis)

When the eggs-and-bacon routine needs a glow up, Southwest Diner blends classic American plates with tacos and custom burritos that bring…

6803 Southwest Ave (St. Louis)

Counter-service chain offering a range of Philly-style cheesesteaks, loaded fries & lemonades.

5 St Louis Galleria St (St. Louis)

Branch of a local chain of family-oriented Italian restaurants serving up pastas, pizzas & entrees.

8831 Ladue Rd (St. Louis)

When you want a low-key brunch move that isn't all hollandaise, Crepes & Treats in the Central West End turns out made-from-scratch crepes…

4630 Lindell Blvd (St. Louis)

A short hop from the Loop, Kingside Diner (CWE) leans into its chess vibe with playful touches and a menu of classic American comfort,…

236 N Euclid Ave (St. Louis)

Restaurant/bar offering BBQ eats & a variety of whiskey options in relaxed, industrial digs.

4900 Laclede Ave (St. Louis)

Cafe chain for health-minded breakfast, brunch & lunch options such as omelets, salads & soups.

8658 Olive Blvd (St. Louis)

Del Bono is Ben Poremba’s wood-fired pizzeria in the Delmar Maker District, turning out artisan pies from a custom-built oven. Grab a…

5232 Delmar Blvd (St. Louis)

Swanky locale at Chase Park Plaza hotel with eclectic bites, cocktails, a poolside patio & billiard.

212 Kingshighway Blvd (St. Louis)

Laid-back restaurant whipping up reimagined Mexican dishes & creative cocktails.

5232 Delmar Blvd (St. Louis)

An extensive menu of Greek options in homey, oak-paneled rooms.

1543 McCausland Ave (St. Louis)

Fast-food chain serving chicken sandwiches & nuggets along with salads & sides.

Parkview Cafe, 4588 Parkview Pl (St. Louis)

Casual spot with a window-service counter preparing Mexican quesadillas and other comfort fare, plus delivery.

4497 Forest Park Ave (St. Louis)

Microbrewery with on-site pub offering small-batch beers & American fare, plus live music & tours.

7260 Southwest Ave (St. Louis)

Storied eatery in the Chase Park Plaza Hotel serves up steaks & cocktails in posh, old-school digs.

232 Kingshighway Blvd (St. Louis)

Mac's Local Eats takes the smash-burger thing seriously, grinding dry-aged whole-cow beef, making condiments in-house, and turning St.…

5656 Oakland Ave (St. Louis)

Local Japanese chain serving rolls, noodles & entrees, plus cocktails, in a chic, modern space.

1 Maryland Plaza (St. Louis)

American chain restaurant offering sizable portions from a vast menu including signature cheesecake

1062 St Louis Galleria St (St. Louis)

Long-running, family-owned Italian restaurant offering generous pizza & pasta dishes.

2103 Sulphur Ave (St. Louis)

Family-run since 1916, Failoni's Restaurant nails that cozy, brick-oven vibe with build-your-own and classic pies plus St. Louis favorites…

6715 Manchester Ave (St. Louis)

Relaxed spot for a drink & casual dining with a waterside view, plus paddleboat rentals.

6101 Government Dr (St. Louis)

Old-school Irish bar serving beer alongside standard pub eats & unique menu items.

6400 Oakland Ave (St. Louis)

Sarpino's Pizzeria Richmond Heights tackles late-night cravings with hand-made specialty pies from Italian tradition and a real vegan and…

6654 Clayton Rd (St. Louis)

Kosher Jewish delicatessen featuring bagels and familiar eats such as corned beef and pastrami.

7608 Wydown Blvd (St. Louis)

Retro, moon-themed hotel eatery with a rooftop terrace bar serving American fare & cocktails.

6177 Delmar Blvd (St. Louis)

Long-running Italian restaurant specializing in old-world-style meat, seafood & pasta entrees.

200 S Brentwood Blvd (St. Louis)

Small, easygoing eatery offering Southern Italian soul cuisine such as seafood pastas & stews.

7600 Wydown Blvd (St. Louis)

Classic American breakfast & lunch offerings plus gourmet coffee in a relaxed setting.

8135 Maryland Ave (St. Louis)

Southern dishes provided in a warm, informal space with an open kitchen, artful decor & patio seats.

8127 Maryland Ave (St. Louis)

Family-owned joint in a strip mall with folksy decor, serving Mexican staples & jumbo margaritas.

887 Kingsland Ave (St. Louis)

Branch of a regional chain dispensing hot & cold sandwiches in a simple, counter-serve setting.

360 Skinker Blvd (St. Louis)

Casual, cozy, trendy spot for classic Mexican recipes plus a choice of margaritas, tequilas and mezcals.

630 North and South Rd (St. Louis)

Plant-forward pescatarian restaurant serving vegan & seafood dishes, as well as creative cocktails.

622 North and South Rd (St. Louis)

Convenience store-based pizza chain doling out create-your-own pies along with wings.

9871 Monarch Dr (St. Louis)

Stand-alone & airport wine bars offering lunch, dinner & small plates with custom-paired wines.

10701 Lambert International Blvd (St. Louis)

Part food truck, part cozy nook, Mr Rivera’s Taqueria turns out legit street tacos, quesabirria, and stacked tortas with salsas that…

900 S Florissant Rd (St. Louis)

Since 1960, Pietro's has been the neighborhood spot for red-sauce comfort, from incredible toasted ravioli to hearty pastas, a dinner salad…

3801 Watson Rd (St. Louis)

Blood & Sand is a refined downtown hideout serving globally inspired plates with cocktails and wines that are nationally recognized, and…

1500 St Charles St (St. Louis)

Burgers, sandwiches & all-day breakfast in a comfy counter-service hub with a fireplace & a patio.

2742 Lafayette Ave (St. Louis)

Some nights this week call for zero fuss and maximum flavor. Pops Pizza & Wings keeps it simple with fresh, saucy wings and hot, cheesy…

601 Chestnut St (St. Louis)

Casual eatery dishing up 30-flavor wings as well as cheesesteaks and burgers, plus salads.

10440 Page Ave (St. Louis)

Cozy Italian eatery serving elevated versions of classic dishes, plus cocktails, and desserts.

48 Maryland Plaza (St. Louis)

Rooster is that bright, European-style café locals brag about, with scratch-made crepes, in-house baked breads, and farm-fresh eggs fueling…

3150 S Grand Blvd (St. Louis)

Counter-serve restaurant doling out creative grilled cheese sandwiches, plus scratch-made soups.

3730 Foundry Way Stall 16 (St. Louis)

Family-friendly buffet chain featuring all-you-can-eat American fare, plus salad & dessert bars.

6110 S Lindbergh Blvd (St. Louis)

Neighborhood eatery serving breakfast staples, sandwiches, specialty drinks & single-origin coffee.

3153 Morgan Ford Rd (St. Louis)

Restaurant offering burgers, shrimp, chicken wings & other eats in an unassuming setting.

7101 Page Ave (St. Louis)